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Onset

/ˈɑˌnsɛt/
B2
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(noun) The initial phase of a disease or condition, in which symptoms first become apparent.

My dad's friend was diagnosed with early onset Alzheimer's disease.
The onset of malaria is marked by nausea, vomiting, fever, chills, and headache.
CEFR Practice Quiz
Doctors recommend early treatment at the ____ of symptoms to prevent the disease from progressing.

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