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Irreversible

/ˌɪrɪˈvɜrsəbəl/
B2
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(adj) Incapable of being reversed or turned about or back; incapable of being made to run backwards.

The death penalty is final and irreversible.
Lead can cause irreversible brain damage.
CEFR Practice Quiz
Climate change is causing ____ changes to the Earth's ecosystems that will affect many future generations.

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