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Exacerbation

/ɪˌɡzæsəˈrbeɪʃən/
C1
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(noun) An increase in the severity of something (such as a disease)

The exacerbation of symptoms was alarming.
The treatment prevented exacerbation.
CEFR Practice Quiz
The patient's condition worsened due to an sudden ____ of her chronic symptoms.

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